منابع مشابه
Neurobiology of Disease Genomic Analysis of Reactive Astrogliosis
Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in response to all CNS injuries and diseases. To better understand the reactive astrocyte state, we used Affymetrix GeneChip arrays to profile gene expression in populations of reactive astrocytes isolated at various time points after induction using two mouse injury models, ischemic stroke and neuroinflammation....
متن کاملRemarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis
Voltage-gated sodium channels (VGSCs) play a vital role in controlling neuronal excitability. Nav1.6 is the most abundantly expressed VGSCs subtype in the adult central nervous system and has been found to contribute to facilitate the hyperexcitability of neurons after electrical induction of status epilepticus (SE). To clarify the exact expression patterns of Nav1.6 during epileptogenesis, we ...
متن کاملCharacteristics of a reactive astrogliosis in multiple sclerosis
A reactive astrogliosis is a prominent feature of the response to injury in the central nervous system (CNS), and studies in both man and animals have provided a well-defined sequence of morphologic changes that accompany these events. However, the contribution of a reactive astrogliois to disease pathogenesis has until recently, remained poorly understood. Now, with the development of transgen...
متن کاملReactive astrogliosis causes the development of spontaneous seizures.
Epilepsy is one of the most common chronic neurologic diseases, yet approximately one-third of affected patients do not respond to anticonvulsive drugs that target neurons or neuronal circuits. Reactive astrocytes are commonly found in putative epileptic foci and have been hypothesized to be disease contributors because they lose essential homeostatic capabilities. However, since brain patholog...
متن کاملReactive Astrogliosis in Epilepsy -Passive Bystanders no more
Submit Manuscript | http://medcraveonline.com potential proand anti-epileptogenic effects [1,2]. Given that epilepsy can be associated with neurodegeneration, mossy fiber sprouting and changes in receptor and neurotransmitter function, examining the specific role of reactive astrogliosis in epilepsy has been fraught with difficulties. Previously, a transgenic mouse line was generated [3] where ...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.6221-11.2012